Formation and Cooperative Behaviour of Protein Complexes on by Ksenia Guseva

By Ksenia Guseva

With the purpose of offering a deeper perception into attainable mechanisms of organic self-organization, this thesis provides new techniques to explain the method of self-assembly and the impression of spatial association at the functionality of membrane proteins, from a statistical physics standpoint. It specializes in 3 vital situations: the meeting of membrane proteins, the collective reaction of mechanosensitive channels and the functionality of the dual arginine translocation (Tat) procedure. utilizing tools from equilibrium and non-equilibrium statistical mechanics, normal conclusions have been drawn that exhibit the significance of the protein-protein interactions. specifically, within the first half a normal aggregation dynamics version is formulated, and used to teach that fragmentation crucially impacts the potency of the self-assembly technique of proteins. within the moment half, by way of mapping the membrane-mediated forces right into a simplified many-body process, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, displaying that protein agglomeration strongly affects its wanted functionality. the ultimate half develops a version that comes with either the agglomeration and shipping functionality of the Tat procedure, thereby offering a finished description of this self-organizing process.

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