Coarse-Grained Modelling of DNA and DNA Self-Assembly by Thomas E. Ouldridge

By Thomas E. Ouldridge

This thesis provides a unique coarse-grained version of DNA, within which bases are represented as inflexible nucleotides. The version is proven to quantitatively reproduce many phenomena, together with elastic houses of the double-stranded nation, hairpin formation in unmarried strands and hybridization of pairs of strands to shape duplexes, the 1st time one of these wide selection of homes has been captured through a coarse-grained version. The scope and strength of the version is confirmed by means of simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker — the 1st time that coarse-grained modelling has been utilized to dynamic DNA nanotechnology.

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